i've never heard of someone plugging a pill that they crushed...i'd imagine that it would be really difficult. the only way i could see this happening is by using the "parachute" method. this is where a person crushes up a pill and then wraps it in toilet paper. this however is usually done when you are going to swallow a pill because it takes less time to break down. with plugging, the membranes are so sensitive that you really don't need to crush it up...it hits hard in like 20 minutes. aside from a lil initial discomfort, i've never known anyone to have a negative experience with plugging.