DO NOT mix stackers w/ e. Over the summer this girl I knew took two hits of e and three stacker 2's (or 3's i'm not sure, do those even exist?). Regardless, let me just say that the girl had no control over her body, she had to be helped and reminded to breathe, and had to be physically helped to keep her from harming herself. She didnt know where she was or what the hell she was doing and everyone was too *scared* to call for help. True, maybe she overdid it but they both increase heart rate and E does wacked stuff if you're rolling hard. My suggestion? Stay away!!