I believe permanent brain damage (if any), along with any other physiological and physical attributes can be represented in chromosomal integrity in future progeny (gametes). But then again, there are SOOO many factors which can cause chromosomal shifts such as cigarette smoking, exposure to pollution, asbestos, and other chemicals as well could lead to sperm and egg prodution with less than a perfect set of 22 "perfect" chromosomes. Unless you rule out theses outside influences you really can't get true results.