Believe it or not! Take two before you start drinking and if possible, take a couple with you and take it sometime during the night (rarely happens since most people are pretty wasted by then!). Then take wo more before you go to bed, 2 advils, 1 multi-vitamin and as much H2O you can drink before passing out. Tea the next morning seems to have some natural soothing and healing qualities as well. CAN'T WAIT!