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WOMEN MORE `HIGHLY STRUNG' Mar 3 2003

Stephen White

WOMEN are born worriers, according to American researchers.

Scientists have discovered that females have lower levels of a brain chemical that affects anxiety.

They found a person with less of the enzyme COMT is more anxious or highly strung.

Women with a certain version of the gene that makes COMT itself worry most of all.

Researchers discovered the strong link between the enzyme and anxiety while investigating the roots of alcoholism.

The US National Institute on Alcohol Abuse combined DNA analysis, recordings of brain activity and psychological tests.

Women with two copies of the particular gene - inherited from each parent - seemed to be the greatest worriers.

However, men having the same genetic make-up did appear to be extra anxious.

Dr Mary-Anne Enoch, of the research team, said: "Our study suggests that women with this genotype may be more vulnerable to anxiety because their COMT levels fall below a minimum threshold."

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