Post Loading and Pre Loading Faqs

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There are at least 3 known systems involved in the effects of psychedelic amphetamines:

1.Serotonergic (Serotonin the mind chemical)

some effect on stomach/Gi upset ect.

Mostly effects mood and thought

5HTryptophan supplementation before and after is helpfull. Some find taking 5HT just before rolling softens blow up. Others feel it makes it harder. Only you wil know by experimentation. Start with 100mg up to 500mg

Safest way is to use with food days before hand. Plan ahead

2.Dopaminergic

This is the energy system and creates euphoria. The amino acid L-tyrosine or the newer N-Acetyl Tyrosine are pre cursors to dopamine. Wihtout dopamine you will not feel the blow up and high. This is why peeps that only use 5Ht don't get the same results as those that use the full preload.

Doses range from 500mg to 2000mg

3.Adrenergic

Adrenaline and Nor adrenaline are neuro's that make you ready to run. They create that scared feeling when you are stressed like when the cop's lights come on from behind ;(.

It is a speedy chemical and helps give you energy but in a different way than dopamine. The amino acid D-L Phenylalanine replaces or maximizes this neuro. Doses range from 500mg to 2000mg.

Last but not least you can take L-Glutamine an aminoi acid that protects the body from losing lean tissue when stressed and acts as an excitatory neuro. Do not confuse this with glutamate the toxic meatbolite.

500mg to 2000mg daily.

St. John's Wort. This natural MAO inhibitors action is unclear but will extend the life of psychedelic drugs. Like betacarbolines used by native the hypericin acts to disable the systems involved in reducing the serotonin levels as well as other sub neuro's.

Vitamin C is a good anti oxidant but probably has no effect either way except to increase solubility of other nutrients because it is an acid. Old acid heads swear that it improves trippy but then again the hippes did some weird shit based on intution rather than science,just as some scientist based too much faith in research rather than intuition It's your call. You should take it for the health of it. A minimum of 1000mg daiy tripping or not.

B-6 will help nerve trans and actions of the above.

Post-load

1 5-HTP 200mg

2 Alpha Lipoic Acid 300mg

3 Anti-oxidant multis

2 Multi-vitamins

3 Milk Thistle 175mg

2 Melatonin 3mg

1 Kava Kava 1000mg

Daily

Taken with meal.

2 Multi-vitamins

2 Multi-minerals

1 Alpha Lipoic Acid 300mg

2 Anti-oxidant multis

2 Milk Thistle 175mg

One of the most important parts is to pre-load with Alpha Lipoic Acid. Another study showed that this also eliminated brain damage from E in rats. (link below). Alpha Lipoic Acid is a very strong anti-oxidant, and taking it in conjunction with an anti-oxidant multiple (containing at least Vitamins C, E, & A) makes it even more effective. A high dose (600mg) is safe and very effective. Milk Thistle is also an anti-oxidant that helps the liver, and thus is an excellent post-load, since you’ve been exposed to many environmental toxins at raves and clubs.

Of course, daily multi-vitamins help to maintain health. Pre-loading with them ensures your body has all it needs to function at its peak.

Magnesium helps stop jaw clenching. 1000mg is very effective.

5-htp is the direct precursor to serotonin. Preloading with this helps because, as the E is dumping out your serotonin, 5-htp is replacing it. This will definitely make you roll longer (probably not harder), and it can possibly help prevent brain damage, since your serotonin supply might not completely run out, although this is theoretical and has not been proven. You must supplement a big dose of B-6 (around 6000% of suggested daily dose) as well as some vitamin C (around 2000% of suggested daily dose) at the time you take 5-htp to ensure it converts to serotonin. Don’t worry, these vitamins are water soluble and big doses won’t hurt you.

Some people report stomach upset with 5-htp, so you may not be able to take very much.

Finally, Kava Kava and Melatonin will help you sleep.

Taking the post-load with fruit juice and fruit rolls helps get some calories back into the body after you’ve been depleted. It’s often difficult to eat afterwards, but fruit rolls seem to go down pretty well. Or any sort of fruit or fruit product is good. Some people recommend protein shakes. I try to drink and eat at least 500 calories before I go to bed, this seems to help a lot.

Here are some links, as well as some outtakes from some of the pages:

Prozac links: http://www.dancesafe.org/slideshow/index.html

(You MUST watch this slide show if you haven’t already, it’s very enlightening.)

Prozac Prevents MDMA Neurotoxicity in Animals

A number of studies have shown that selective serotonin reuptake inhibitors (SSRIs) like Prozac prevent MDMA's neurotoxic effect. The theory as to why this happens is this: SSRIs plug the reuptake transporters, thus preventing dopamine from getting into the serotonin axon terminal (see the previous slide). Notice that the prozac fits pefectly into the transporter. Researchers refer to this as "affinity" and say that prozac has a greater affinity for the uptake transporter than other things in the synapse, including serotonin. In other words, Prozac will bind to the transporter first. It will also stay there for a relatively long time. Prozac has a half-life of 30 hours, which means it takes 30 hours for half of it to leave your body, another 30 hours for half of what's left to leave, etc. It is thus called a "long-acting" SSRI. It plugs the transporters for a longer period of time than the other common SSRIs do. Research has shown that brain serotonin levels remain significantly depleted for approximately 24 hours after a lage dose of MDMA. It is during this time period (beween 6 and 24 hours after dosing) that the brain's serotonin transporters are left empty and vulnerable, and it is during this time that the neurotoxic damage occurs. This means Prozac may be more effective at preventing MDMA neurotoxicity than other SSRIs, which do not last as long in the body (although this is unknown).

An important observation in these studies was that prozac prevented the neurotoxic damage even when given up to six hours after the MDMA. What they did was inject all the animals with MDMA, and then every hour they gave some of them an injection of Prozac. Only the animals who got the Prozac during the first six hours showed no damage. The ones who got the Prozac on the seventh, eighth, ninth and tenth hours (etc.) sustained damage, with the ones who got the prozac later sustaining more.

What about in humans?

While no studies have been done to assess the effectiveness of Prozac as a neuro-protective agent against MDMA neurotoxicity in humans, there is no reason to suspect that human brains react differently than animal brains in this regard. http://www.maps.org/news-letters/v04n3/04304neu.html

Animal research has shown that combining the prescription drug Prozac with MDMA prevents neurotoxicity, even when Prozac is taken up to six hours after the MDMA. This works because Prozac binds to the same serotonin re-uptake sites which can be damaged by MDMA metabolites (though only when MDMA is administered at doses higher than the standard therapeutic or non-medical amount). The presence of Prozac at the re-uptake sites prevents the neurotoxic MDMA metabolites from binding, eliminating its potential effect on the re-uptake sites. http://mdma.net/protect.htm

The FLUOX (Prozac) pretreatment protected against MDMA-induced 5-HT and 5-hydroxindole acetic acid depletions in the frontal cortex, somatosensory cortex, striatum and hippocampus. http://mdma.net/mdmafluox.html

These results support previous findings that fluoxetine (Prozac) protects against (+/-)-MDMA-induced 5-HT (serotonin) depletion. http://www.maps.org/news-letters/v01n3/01305neu.html

The simultaneous administration of Prozac and MDMA completely blocked the neurotoxic properties of MDMA. This finding may be the key to unlocking the door to FDA-approved human studies with MDMA, since it seems possible that the MDMA neurotoxicity risk, difficult to estimate, can instead be entirely eliminated.

Alpha Lipioc Acid links: http://www.mdma.net/alphalip.html

Repeated administration of the metabolic antioxidant alpha-lipoic acid (100 mg/kg, i.p., b.i.d. for 2 consecutive days) 30 min prior to MDMA did not prevent the acute hyperthermia induced by the drug; however, it fully prevented the serotonergic deficits and the changes in the glial response induced by MDMA. These results further support the hypothesis that free radical formation is responsible for MDMA-induced neurotoxicity. http://www.gnc.com/wellness/natpharm/Supp/Alpha_Lipoic_Acid-F.htm

Alpha lipoic acid is a vitamin-like antioxident. Alpha lipoic acid is sometimes referred to as the “universal antioxidant,” because it is soluble in both fat and water.

Anti-Oxident (Vitamins C, E, A, etc. See this link for complete list) link: http://www.gnc.com/wellness/natpharm/Diet/Antioxidants-F.htm

Reducing exposure to free radicals and increasing intake of antioxidant nutrients can reduce the risk of free radical-related health problems. (such as MDMA neurotoxicity)

Milk Thistle link: http://www.hcrc.org/faqs/milkthis.html

5-htp links: http://www.mindspring.com/~herbshop/5htpfact.htm http://www.smart-publications.com/5-htpbook.html

Grapefruit Juice link: http://www.media.wayne.edu/iws.back.issues/iws3_6_97/grapefruit.html

Good link for info on nearly all nutritional supplements: http://www.gnc.com/wellness/natpharm/Index/SuppX-F.htm

Buy your Prozac legally and without a prescription at: http://www.smart-drugs.com/

Buy your nutritional supplements from such stores as: http://www.iherb.com/ http://www.mothernature.com/ http://www.drugstore.com/ http://www.planetrx.com/

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~*P*L*U*R*~

Four Simple Words To Live By....

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I forget where I found this article, but it's one of the best I have ever seen. Also one of the most thorough. I have added some corrections and adjusted the dosages on the vitamins.

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~*P*L*U*R*~

Four Simple Words To Live By....