djscotphreak Posted February 14 Report Share Posted February 14 Allaying Imbalance in your NeurochemistryThere is some evidence that taking Melatonin can prep your neurochemistrybefore MDMA or reboot your brain after taking MDMA. There is also somepractice of taking ONE SSRI (Selective Serotonin Reuptake Inhibitor, e.g.Prozac, Zoloft, or Paxil) the morning after, for that's when the damagehits - the two days after ingestion. It stops the effects of MDMA in itstracks, but should prevent any neurotransmitter damage. But taking too muchcan result in a hypertensive crisis and a near fatal response. You'replaying with fire, is it REALLY worth it?Pre-loading is an attempt to enhance the good effects of MDMA and reduce thenegative ones. These vitamins and amino acids are all available from healthfood shops. Many people who have tried pre-loading say that it helps agreat deal. The most important one to take is 5-HTP which is a precursor ofserotonin. But 5HTP can make the experience so intense as to be morepotentially damaging to vulnerable individuals.Pre-loading with precursors of the neurotransmitters depleted by MDMA willgive you a better roll and ease your comedown.Dr. Tom Oth writes (in the MDMA Clearinghouse Forum):1. 200-500mg 5-hydroxytryptophan (5-HTP)2. 500-1000mg tyrosine3. 500-1500mg DLPA4. 2 grams glutamine5. 1 gram of vitamin CTake 1 hour before rolling with some grapefruit juice. The sugar will spikeyour insulin and help the aminos cross the blood brain barrier. You will beamazed.1-3 are amino acids, precursors of serotonin, dopamine & noradrenaline. 4 isanother amino acid - it's like glucose for the brain.5 is required for neurotransmitter production and is a good antioxidant.5-HTP is the most important supplement so don't be tempted to skip it. Ifyou don't want to neck all that lot then skip the Tyrosine & DLPA, althoughthey do have a noticeable effect in most people. I would take it about anhour ahead of time and the juice does make a difference.The basic idea is that MDMA will deplete stores of the neurotransmitters inyour brain. The MDMA experience is largely caused by your neurons firingrapidly and releasing Serotonin & Dopamine. Supplementing your diet with theprecursors to these neurotransmitters will ensure that you get the maximumout of the MDMA. The supplements are not drugs themselves, they arenutrients.Serotonin = empathy, contentment, bliss, love, head rushesDopamine = energy, euphoria, body rushes ((the 'speedy' effect)5-HTP replaces Serotonin. Tyrosine & DLPA replace Dopamine. DLPA also hasother functions but I'm not clear on them and they're not too important inthis context. These aminos will circulate in the bloodstream and some willcross the Blood-Brain Barrier and be synthesised into the appropriateneurotransmitter.Take one hour before dropping your pill. Any fruit juice will do by the way.I usually take Cola anyway for the additional caffeine. You should not eatfor 3-4 hours before you drop. If you get hungry eat foods containing noprotein as proteins will break down into amino acids and reduce the effectof the pre-load. You should get a longer & stronger roll and not feel sofucked afterwards.Additional information contributed by Kallisti -Malaclypse the Youngst KSC(Mal-3) :Magnesium cuts down on jaw clenching. B6 is required for the conversion of5-HTP into 5HT so taking some Vitamin B6 might help. 5-HTP should be takenafter, maybe with an SSRI (prozac, Zoloft, etc) to cut down on the axontrimming and serotonin depletion that occurs afterwards and createstolerance and "Post-E Depression".------------------Do You?? Quote Link to comment Share on other sites More sharing options...
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