Sometimes I feel down, sometimes I don't. It might depend on the hit or how much you take. Or if there are other things in your life that would naturally cause depression, e or no e. As long as you don't trip every weekend, you shouldn't get severely depresssed. I roll maybe every 4-6 weeks. It's not like I fiend for it though if I go longer than six weeks. I have friends that trip only twice a year. Don't get me wrong, I spent two summers tripping almost every weekend, but I never got severly depressed. I'm almost sure the following is true (I'm not a dr. or anything). The depression is caused by your brain overloading with serotonin when you trip. So after tripping, your serotonin levels are low. Supposedly, it takes about two weeks for your brain to get serotonin levels back to normal.