liljewlz

to maxx 77: shoot i just wrote the whole damn thing out and lost it- but here it goes again seratonin (and dopamine) are condsidered amine nuerotransmitters- the level of amines in the brain can be altered by inhibiting the their re-uptake in the nerve endings (when nuerotransmitters are released-not all are takin up by the next cell over- instead some float back into the previous cell and are broken down- not allowing the full capacity to be recieved by the other nueron)-or by inhibiting the the activity of the enzymes which metabolize the amines- MAO (monoamineoxidases) are responsible for the reuptake and therefore dissolution of the amines- prozac, welbutrin, zoloft,etc...are exactly MAO inhibitors- they prevent the reuptake of the amines by the releasing cell-this is all good and dandy for depressed people- but when you roll- the same proteins that release the seratonin- also take it back up- so by blocking those channels- you wont roll when mdma is in your system- not all the seratonin can rush out at once instead it happens more slowly- so u may feel good- but not quite "oh - god damn this is good!!!" so my advice is stay away while rolling!!!! but...after you roll it may be benficial to your emotional well-being and also to the health of your neurons- not only will it help u defeat the post-e blues by doing all that good stuff i said before (aka its job)- think back to when i was talking about hydrogen peroxide being produced from the uptake of seratonin to the wrong parts of cells- these protein channels are nonspecific to the amine they release or uptake- and therefore- niether is the medication- in effect, prozac, etc... may help prevent killing your nueron from the unwanted seratonin uptake by blocking those channels as well i hope this helps luv ya jewelz ------------------ the most successful people in life only look ahead to the great hpriszon of possibilities

hey kids for all you wondering about what e really does to you- well here's what i figured out after all my years as a med student in the field of nueropharmacology...ill try to be as nonscientific as possible first- when mdma is ingested into the blood stream, 1)broken down by the cyp-26b enzyme in your liver 2)broken down in your cerebral nuerons - when this happens, amino acids (the main ones being methionine and tryptophan) come to together to form your oh so favorite nuerostransmiiter, seratonin, when the concentration of seratonin builds up in the nuerons- it is released through protein channels down its concentration gradient, from there it travels through the plasma surrounding your nuerons and into other synaptic terminals (other nerve endings) in your brain from there it is picked up by transport protiens into the nueron whjere it is broken down to form a concentration gradient of (both chemical and electric- think back to your high school chemistry when molecules where broken down to form chanrged particals)- from there your nuerons fire sending siganls to your hypothalmus (nesr the middle-back of your brain0 the part responsible for emotion)making you feel oh so free the recovery period- seratonin takes awhile to break down- like oh geez- four hours (any coinicidence- i think not)- and thats where your roll comes in- as long as relatively high levels of seratonin are running through your brain- yet it also takes even longer to build up- like up too a day-(to be able to feel a roll again)- but fully by 2-3 weeks (thats only for your veteran rollers- since your brain is getting used to the idea of being seratonin depleted- its stops producing as much - because- as to be explained later- its somewhat hazardous to your health) ok- now here's why people are sayind e is bad- but first i have to explain the nuerotransmitter dopamine (the one responsible for your feelin on yabs- cocaine)- when you blow a line of coke same thing happens but dopamine is the nuerotransmitter - and its broken down in twenty minutes and rebuilt in about an hour or so- both of these nuerotransmitters are running through your bain on a regular basis- both able to be picked up by the same transport proteins- BUT- when seratonin is picked up by by a nueron meant for dopamine- it will be broken down to form nydregen peroxide in your nueron- effectively killing it (think when you put that shit on an open cut)- and as you may know- nuerons are irreplacable- ps to this- if high levels of both are in your brain (or when u do coke and e)- the seratonin has less of a chance to get where it needs to go- this is why coke stops your roll- and i know some of you may think that soem e pills have coke in the,- but just remeber how quickly dopamine is burned and rebuilt- even beofre you roll... also- even from the first time you roll- your body builds up a life long tolerance to mdma- making it impossible to get that first roll back...ahh so sweet...and in terms of your mood- it actually helps- dec impulse urges- so people who roll seem to be just a lil more relaxed and laid back- so its not all a bad thing other drugs: beware of dxm!!!- it acts on the same level as e- but causes the dissactioative effects seen with k- and is but it doesnt allow you sweat which i can't stress how hazardous that is to your health!!!- if u dont sweat your body heats up- your proteins denature- and u die!!-also it is broken down by the same cyp-26b enzyme in the liver- making combining the 2 a very deadly combo- well thats all i think of for now- i think everyone should know what goin on in the body to make a concious shoice luv ya all jewelz any q's please ask

HEY ALL YOU PEEPS IN THE B-LO- WHATS HAPPENING TO CLUB E?- ITS THE ONLY CLUB IN BUFFALO- MAYBE CRYSTAL COMES CLOSE- TO PLAYIN DOPE BEATS AND HOUSING SOME SWEET DJ'S!!!- LETS NOT LET IT GET SO GHETTO LIKE TUNNEL!!!!- GO NICELY DRESSED LIKE YOU WOULD IN ANY OTHER CITY AND LETS TAKE IT BACK!! ------------------

HEY GUYS WHY THE HELL ISNT ANYONE IN THE CHAT ROOMS- WE ALL KNOIW IF WE KNOW ENOUGH TO FIND THIS SIGHT AND SIGN UP- WE SPEND ENOUGH TIME AT OUR COMPUTER TO KNOW THAT THESE CHATROOMS HAVE HELLUVALOTTA POTENTIAL COMPARED TO AOL!!- NUFF SAID- WHO'S WITH ME!!!! ------------------

everyonr be sure to check this out!!!!- $15 bucks at the door- at the roller rinks at chelsea piers (pier 62)- WEST 23RD ST AND HUDSON RIVER- FOR DIRECTIONS CHECK OUT WWW.CHELSEAPIERS.COM ------------------

does anyone know when wink is gonna be at twilo? ------------------

hey if you guys can- go find someone who has a membership to rise (or get one yourself!!)- its an after hours clyd on stuart st- very underground- but one floor looks like the house parties everyone goes to afterwards but is well stocked (but a bit pricy) beverages for all those who are thirsty after a night of "ya know"- the other floor is every single wonderful beat you could think of - from house, d&b, trance, whatever you take your pick its awesome- and for all those who want to get to know those avalon dancers- ive definately spotted a few of them there!!! ------------------

if you guyhs want a place to sit and chill to some great music and buddah meets spanish fly scene- where apparently some of the most famous creativity of america has come from- go check it out- you just might be insprired yourself ------------------

you have to check out the creativity and detail at this venue- its the small things like the chair neart the dance floor will give your weight- the waterfall behind the bar- the bathrooms are saunas- the tials on the wall are dial soaps- go check it out!!! ------------------