I went to NY to check out S&D at Twilo last month. We don't have anything quite like that. However, there is a good scene. Lots of good local talent and a lot of the intl DJs find there way here. The Guv't has a killer sound system as pointed out above. I like some of the smaller clubs like System and Turbo or Element. Check out www.eye.net for a schedule of DJs. It is posted on Thursdays.