SF is about 7 hrs away, so peeps go there sometimes, but it's kind of a hike. Some clubs close at 2am (which is when they stop serving drinks), but others, especially the big ones (Giant, Spundae) stay open till 4 or 5 am. There are afterhours, and some are pretty good, but others are crack dens. Post closer to your trip and we'll be able to give more specific info. NYC is awesome, btw (as I'm sure you know ) I went to school there.