Empire Ballroom is the new afterhours hotspot for Saturday nights. I've heard some good things about it, but I'm always too tired to go there after I get off work. Also, a popular spot for locals is Rainbow Bar...it's pretty much an all night all morning type place. Big bar, delicious food, and a friendly staff. The music is usually rock (not a fan), but it's a place to sit around and have some drinks and food at 5 or 6 in the morning. A good combo would be Body English on a Friday night and then walking across the street to Rainbow Bar (just don't get hit by traffic if you are drunk!), and Saturday hit one of the other big clubs and then cab it over to Empire.