iv bin dooing e fur 20 yearz anf thier iz nthng wong with mE!! hehe seriously no one really knows the long term effects cause it just hasnt been around that long. The people who you see catscans on TV and have holes in their head did EVERY drug know to man. That said E will probably fry your axons after awhile leading to various problems (chronic depression, mem lose, ect.). After i started taking 2 a night and not feeling anything i figured its time to give it up. 5 a night? Is it really that much fun at that point?