Pre- and post-loading isn't for the effect, it's for not feeling like a crackhead fucktard the next day, and reducing the s*****ty of the brain damage/depression. For anyone seriously interested in pre-/post-loading, here's a doc I saved a long time ago. It's more than I care to worry about, I'll stick to 5-htp the days before and the week after, and not do E every month.