k is a very safe substance, i've mixed it with many other drugs as well and done high doses without any harm. i'm a 150 pound male, and have gone as far as to binge (yes addictive, so be careful) 7 grams in 5 days, and felt fine after i slept it off for a night. start slow with k, it's a lot more intense in the beginning, whereas later down the line, it loses its novelty and you're kinda like "oh yeah, i'm in a k-hole" and it takes a whole gram to have any fun. as a respiratory depressant, it's not smart to do with downers, including alcohol. LD50 is 4500 mg, or 4 and a half vials snorted more or less at one time. that's more k than i can do, and i love the stuff. be careful kiddies, and here's a link to everything you could ever want to know and more about k- (dancesafe doesn't elaborate on anything very well) ->> http://www.erowid.org/chemicals/ketamine/ketamine_dose.shtml and a link to every other drug's info you could dream of ->> http://www.erowid.org/psychoactives/psychoactives.shtml enjoy and be careful!