Combining ecstacy and prozac is a definate no, no. I have this friend who was on prozac due to her depression problems. On weekends we used to go to this kids house to roll, dance, and have a good time. After awhile she became distant and stopped hanging out with us. I had noticed she was out of school for about a week and when she came back she was trying to hide the slash marks on her arms. She had been in the hospital because she was slitting her wrists, probably the results of combining the two drugs.