everyone reacts to everything differently. i used to take 3-8 pills of 25 mg. ephedrine everyday. i'm quitting now; at about 2/day. i seem to be fine with ephedrine, but i react differently with ephedra. ephedra gives me stomach and muscle cramps, makes me nauseous, etc. i don't think you can take one case and apply it to everyone. if you want to be careful, don't mix anything. complementary drugs will have an multiplier effect on each other, and contrasting drugs will confuse your body. be extra safe and don't do anything ;-) personally, when i am getting ready for a crazy night out, i drink a full cup of whole milk ibuprofen (which is what advil is) is the only otc painkiller you CAN safely take with alcohol. aspirin, acetaminophen, codeine, etc., are known to have caused deaths and health problems when consumed with alcohol. alcohol has been known to have caused deaths and health problems when consumed with alcohol ------------------ better to reign in hell than serve in heaven